Publications

    mt-ccc-review

    Daisy L. Wong, Martin J. Stillman
    Reference Module in Chemistry, Molecular Sciences and Chemical Engineering, 1 2020

    Abstract: Since their discovery in 1957, metallothioneins (MTs) are now known to be involved in a variety of biochemical pathways. These include metal regulation and metabolism of metals both toxic and beneficial. Often, MTs expressed in select species are used as biomarkers for heavy trace elements in the environment, as they are easily accumulated by MTs. MTs are also believed to mitigate reactive oxygen species damage and protect against neurodegenerative diseases. Recently, with the popularity of metal-based therapeutics, MT's metal detoxification properties have become... Read more


    bi6mt

    Korkola, N. C., Scarrow, P. M., & Stillman, M. J. (2020). pH dependence of the non-cooperative binding of Bi 3+ to human apo-metallothionein 1A: kinetics, speciation, and stoichiometry. Metallomics, 12(3), 435-448.

    Abstract: Bismuth is a well-known therapeutic agent that is used primarily for treatment against peptic ulcers. It has also had success in protecting against nephrotoxicity caused by the anticancer compound cisplatin by inducing... Read more


    cd2

    Yuan, A. T., Korkola, N. C., Wong, D. L., & Stillman, M. J. (2020). Metallothionein Cd 4 S 11 cluster formation dominates in the protection of carbonic anhydrase. Metallomics.

    Abstract: Metallothioneins (MTs) are ubiquitous proteins vital for essential metal homeostasis and heavy metal detoxification. The twenty-cysteinyl mammalian metallothioneins protect the proteome by sequestering heavy metals... Read more


    borondif

    Dhindsa, J. S., Melenbacher, A., Barbon, S. M., Stillman, M. J., & Gilroy, J. B. (2020). Altering the optoelectronic properties of boron difluoride formazanate dyes via conjugation with platinum (ii)-acetylides. Dalton Transactions.

    Abstract: The combination of π-conjugated organic compounds and Pt(II)-acetylides is a powerful strategy for the production of functional optoelectronic materials... Read more

    bf2formdye



    Melenbacher, A., Dhindsa, J. S., Gilroy, J. B., & Stillman, M. J. (2019). Unveiling the Hidden, Dark, and Short Life of a Vibronic State in a Boron Difluoride Formazanate Dye. Angewandte Chemie International Edition, 58(43), 15339-15343.

    Abstract: Boron difluoride (BF2) formazanate dyes are contenders for molecular species that exhibit a large Stokes shift and bright red emission. Excitation of 3‐cyanoformazanate complexes with 10 μs wide pulses of... Read more


    staph

    Verstraete, M. M., Morales, L. D., Kobylarz, M. J., Loutet, S. A., Laakso, H. A., Pinter, T. B., ... & Murphy, M. E. (2019). The heme-sensitive regulator SbnI has a bifunctional role in staphyloferrin B production by Staphylococcus aureus. Journal of Biological Chemistry, 294(30), 11622-11636.

    Abstract: Staphylococcus aureus infection relies on iron acquisition from its host. S. aureus takes up iron through heme uptake by the iron-responsive surface determinant (Isd) system and by the production of iron-scavenging siderophores. Staphyloferrin B (SB) is a siderophore produced by the 9-gene sbn gene cluster for SB biosynthesis and efflux... Read more







    copperchalc

    Polgar, A. M., Zhang, A., Mack, F., Weigend, F., Lebedkin, S., Stillman, M. J., & Corrigan, J. F. (2019). Tuning the Metal/Chalcogen Composition in Copper (I)–Chalcogenide Clusters with Cyclic (Alkyl)(amino) carbene Ligands. Inorganic chemistry, 58(5), 3338-3348.

    Abstract: A series of phosphorescent homo- and heterometallic copper(I)–chalcogenide clusters stabilized by cyclic (alkyl)(amino)carbene ligands [Cu4M4(μ3-E)4(CAACCy)4] (M = Cu, Ag, Au; E = S, Se) has been synthesized by the reaction of the new copper(I) trimethylsilylchalcogenolate... Read more


    plaxenone



    Knott, M. G., de la Mare, J. A., Edkins, A. L., Zhang, A., Stillman, M. J., Bolton, J. J., ... & Beukes, D. R. (2019). Plaxenone A and B: Cytotoxic halogenated monoterpenes from the South African red seaweed Plocamium maxillosum. Phytochemistry letters, 29, 182-185.

    Abstract: The endemic South African red seaweed Plocamium maxillosum (Poiret) Lamouroux produces two unusual isomeric dichlorinated cyclohexenone monoterpenes, plaxenone A and B (1 and 2). The structures of the isolated... Read more


    alfe

    Ott, D. B., Hartwig, A., & Stillman, M. J. (2019). Competition between Al 3+ and Fe 3+ binding to human transferrin and toxicological implications: structural investigations using ultra-high resolution ESI MS and CD spectroscopy. Metallomics, 11(5), 968-981.

    Abstract: Human serum transferrin (hTF) is an iron binding protein with the primary task of ensuring well-controlled transport of Fe3+-ions in the bloodstream. Furthermore, hTF has been identified as a key component in the trafficking... Read more


    cdpathways

    Wong, D. L., Korkola, N. C., & Stillman, M. J. (2019). Kinetics of competitive Cd 2+ binding pathways: the realistic structure of intrinsically disordered, partially metallated metallothioneins. Metallomics, 11(5), 894-905.

    Abstract:  The 20-cysteine mammalian metallothioneins are considered to be central to the homeostatic control of the essential metals Zn(II) and Cu(I) and, as part of their metal-loaded status, play a role in reversing oxidative... Read more

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